Blog Post

TAKiR uses the H3Africa Array with 2.26 million markers!

LaKisha David | Aug. 29, 2019, 1:46 a.m.

TAKiR uses the Infinium H3Africa Array (Illumina) with 2.26 million markers! The array design was submitted by the Human Heredity and Health in Africa (H3Africa) consortium design team. Our samples are analyzed by the Functional Genomics Unit of Roy J. Carver Biotechnology Center.

One of TAKiR's core projects involves encouraging northern Ghanaians to take an autosomal DNA test to help people of African descent discover their relatedness among the Ghanaian peoples. Previously, we have relied on the services of AncestryDNA. In continuing our efforts to construct the genealogy of the Kassena people, we are excited to announce that we are now moving into higher density testing by using an array with 2.26 millions markers that is designed for the study of African populations.

TAKiR IBD Workflow:

The H3Africa Array is manufactured by Illumina. DNA extraction services are being provided by the Freund Lab. Genotyping services are being provided by the Functional Genomics Unit. Both of these labs are part of the Roy J. Carver Biotechnology Center at the University of Illinois at Urbana Champaign.

We are using Plantimals/2vcf to format our genotype files. To phase and identify matching segments among the Kassena people, we are using the scientifically studied BEAGLE 4.0 for family-based phasing and identity-by-descent detection (or BEAGLE 5.0 for computational phasing and Refined IBD for identity-by-descent detection).

Having the genotype files that were provided by AncestryDNA uploaded to GEDmatch helped people of African descent to identify their relatedness among the Kassena people. We will soon provide the option for relatives who previously learned of their relatedness through GEDmatch to also upload their DNA profiles to TAKiR. Whereas relatives need to also test with the H3Africa array to take advantage of those markers provided in addition to the AncestryDNA markers, they will be able to identify relatedness based on those markers shared across both AncestryDNA and H3Africa arrays. We will also provide the option for relatives to test with the H3Africa array.

Your Support:

Consider supporting the work of TAKiR by donating for batch 2. Even $5 would be helpful.

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